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ReportsandReports Announce it Will Carry Pulmonary Arterial Hypertension (PAH) – Pipeline Assessment and Market Forecasts to 2016 Market Research Report in its Store.
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GlobalData’s report, “Pulmonary Arterial Hypertension (PAH) – Pipeline Assessment and Market Forecasts to 2016” provides an essential source of information and analysis on the global PAH market. The report identifies the key trends shaping and driving the global PAH market. The report also provides insight on the competitive landscape and the emerging players expected to cause significant shifts in the positioning of the existing market leaders. Most importantly, the report provides valuable insight into the pipeline products within the global PAH sector.
This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalData’s team of industry experts.
GlobalData valued the global Pulmonary Arterial Hypertension (PAH) market to be worth $2,653m in 2009. According to the Venice 2003 revised classification system, PAH is categorized as World Health Organization (WHO) Group I – PAH. Prior to 2001, no drug was approved for the treatment of PAH. Only supportive care medication such as anticoagulants, diuretics, oxygen, digoxin and calcium channel blockers was given to the patients. In 2001, the US Food and Drug Administration (FDA) approved Tracleer as the treatment for patients with PAH. This drug is a registered trademark of Actelion Ltd. The sales of Tracleer grew rapidly due to a high patient switch over from off-label drugs to Tracleer. The drug has a better efficacy profile compared to the previously used off-label drugs.
The FDA also approved three more drugs, Remodulin, Ventavis, and Revatio in 2002, 2004 and 2005 respectively for the treatment of PAH. However, these three drugs accounted for only a 24% market share to PAH market in 2005. Between 2005 and 2009, the PAH market grew at a Compound Annual Growth Rate (CAGR) of 39.2% and recorded revenues of $2,653m in 2009. According to GlobalData analysis, the PAH market is forecast to grow at a CAGR of 5% annually over the next six years to reach $3,569m by 2015. Tracleer, the major revenue generating drug of the PAH market is expected to go off patent by 2015. The patent expiry of this drug will be a major barrier for the market growth. Until this time, the growth of the PAH market is primarily attributed to increased competition among existing products, the release of new and enhanced treatment options, and the development of safer and more efficacious therapies. In 2009, Actelion Ltd, with its key drug Tracleer, was the leading player in the global PAH market.
Scope
The report analyzes market opportunities and challenges for the global PAH market. Its scope includes
- Annualized global PAH market revenues data from 2005 to 2009, forecast forward for seven years to 2016.
- Geographic markets covered in this report include the US, the UK, Italy, Spain, Germany, France, and Japan.
- Pipeline analysis data provides a split across different phases, mechanism of actions being developed and emerging trends. Key classes of mechanism of action include endothelin receptor antagonists, platelet aggregation inhibitors, phosphodiesterase inhibitors, serotonin pathway antagonists, angiotensin receptor antagonists, P2Y 12 receptor inhibitors, PDE5 inhibitors, prostacyclin (PGI2) agonists, nitric oxide synthetase inhibitors.
- Analysis of the current and future market competition in the global PAH market. Key market players covered are Actelion Ltd., United Therapeutics Corporation, Bayer AG, Gilead Sciences, Pfizer Inc., Novartis AG, Bristol-Myers Squibb, Sanofi-Aventis, Eli Lilly and Company, Lung RX and GlaxoSmithKline Plc.
- Insightful reviews of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.
- Key topics covered include strategic competitor assessment, market characterization, unmet needs and the implications for the future market associated with PAH.
Reasons to buy
The report will enhance your decision making capability in a rapid and time sensitive manner. It will allow you to:
- Develop and design your in-licensing and out-licensing strategies through reviews of pipeline products and technologies and by identifying companies with the most robust pipeline.
- Develop business strategies by understanding the trends shaping and driving the global PAH market.
- Drive revenues by understanding key trends, innovative products and technologies, market segments and companies likely to impact the global PAH market in future.
- Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors.
- Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain competitive advantage.
- Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and strategic partnerships.
- What is the next big thing in the global PAH market landscape? – Identify, understand and capitalize.
1 Table of contents 3
1.1 List of Tables 5
1.2 List of Figures 5
2 Pulmonary Arterial Hypertension Market: Market Characterization 6
2.1 Overview 6
2.2 Pulmonary Arterial Hypertension Market Size 6
2.3 Pulmonary Arterial Hypertension Market Forecast and CAGR 7
2.4 Drivers and Barriers for the Pulmonary Arterial Hypertension Market 8
2.4.1 Drivers for the Pulmonary Arterial Hypertension Market 8
2.4.2 Barriers for the Pulmonary Arterial Hypertension Market 9
2.5 Opportunity and Unmet Need 9
2.6 Key Takeaway 11
3 Pulmonary Arterial Hypertension Market: Competitive Assessment 12
3.1 Overview 12
3.2 Strategic Competitor Assessment 12
3.3 Product Profile for the Major Marketed Products in the Pulmonary Arterial Hypertension Market 13
3.3.1 Tracleer 13
3.3.2 Remodulin 14
3.3.3 Revatio 15
3.3.4 Ventavis 16
3.3.5 Letairis 17
3.3.6 Adcirca 19
3.4 Key Takeaway 23
4 Pulmonary Arterial Hypertension Market: Pipeline Assessment 24
4.1 Overview 24
4.2 Strategic Pipeline Assessment 24
4.2.1 Technology Trends Analytical Framework 24
4.3 Pulmonary Arterial Hypertension Therapeutics – Promising Drugs under Clinical Development 26
4.4 Molecule Profile for Promising Drugs under Clinical Development 27
4.4.1 Iloprost 27
4.4.2 ACT-064992 27
4.4.3 Oral Treprostinil 28
4.4.4 ACT-293987 28
4.4.5 Riociguat (BAY63-2521) 29
4.5 Pulmonary Arterial Hypertension Pipeline – Pipeline by Clinical Phases of Development 30
4.5.1 Pulmonary Arterial Hypertension Therapeutics – Phase III Clinical Pipeline 31
4.5.2 Pulmonary Arterial Hypertension Therapeutics – Phase II Clinical Pipeline 32
4.5.3 Pulmonary Arterial Hypertension Therapeutics – Phase I Clinical Pipeline 34
4.5.4 Pulmonary Arterial Hypertension Therapeutics – Preclinical Pipeline 34
4.6 Discontinued/ Suspended Drugs for Pulmonary Arterial Hypertension 35
4.7 Key Takeaway 35
5 Global Pulmonary Arterial Hypertension Market: Implications for Future Market Competition 36
6 Pulmonary Arterial Hypertension Market: Future Players in the Pulmonary Arterial Hypertension Market 38
6.1 Introduction 38
6.2 Actelion Ltd. 39
6.2.1 Company Overview 39
6.2.2 Business Description 39
6.2.3 Company Pipeline 40
6.3 United Therapeutics Corporation 40
6.3.1 Company Overview 40
6.3.2 Business Description 40
6.3.3 Company Pipeline 41
6.4 Bayer AG 41
6.4.1 Company Overview 41
6.4.2 Business Description 41
6.4.3 Company Pipeline 42
6.5 Gilead Sciences 42
6.5.1 Company Overview 42
6.5.2 Business Description 43
6.5.3 Company Pipeline 44
6.6 Pfizer Inc. 44
6.6.1 Company Overview 44
6.6.2 Business Description 44
6.6.3 Company Pipeline 45
6.7 Novartis AG 45
6.7.1 Company Overview 45
6.7.2 Business Description 45
6.7.3 Company Pipeline 46
6.8 Bristol-Myers Squibb 46
6.8.1 Company Overview 46
6.8.2 Business Description 47
6.8.3 Company Pipeline 47
6.9 Sanofi-Aventis 47
6.9.1 Company Overview 47
6.9.2 Business Description 48
6.9.3 Company Pipeline 48
6.10 GlaxoSmithKline 48
6.10.1 Company Overview 48
6.10.2 Business Description 49
6.10.3 Company Pipeline 49
7 Pulmonary Arterial Hypertension Market: Appendix 50
7.1 Definitions 50
7.2 Abbreviations 50
7.3 Research Methodology 52
7.3.1 Coverage 52
7.3.2 Secondary Research 53
7.3.3 Forecasting 53
7.3.4 Primary Research 56
7.3.5 Expert Panels 56
7.4 Contact Us 56
7.5 Disclaimer 56
7.6 Sources 57
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